Rare primary anorectal malignant melanoma presenting with painless hematochezia: a case report

This case underscores that ARMM can be clinically indistinguishable from rectal carcinoma, posing a high risk of misdiagnosis. It highlights the critical role of histopathology and immunohistochemistry (IHC) in definitive differentiation, emphasizing the necessity of accurate diagnosis through IHC. Finally, it demonstrates the evolving treatment paradigm from extensive surgery toward a multidisciplinary approach integrating radical resection with adjuvant immunotherapy, reflecting advances in molecular insights and ameliorated outcomes.

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Publication Details

Journal
Frontiers in Oncology
Published
2025-08-20
DOI
https://doi.org/10.3389/fonc.2025.1640063
Primary Topic
Cutaneous Melanoma Detection and Management
Type
article
Field-Weighted Citation Impact
0.00

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article

Rare primary anorectal malignant melanoma presenting with painless hematochezia: a case report

Yu‐Liang Zou, Yuchun Zhong, Wei Xu, Xiao Hu et al.
Frontiers in Oncology
Cutaneous Melanoma Detection and Management
article

Rare primary anorectal malignant melanoma presenting with painless hematochezia: a case report

Yu‐Liang Zou, Yuchun Zhong, Wei Xu, Xiao Hu, Lihong Peng
article en

Abstract

This case underscores that ARMM can be clinically indistinguishable from rectal carcinoma, posing a high risk of misdiagnosis. It highlights the critical role of histopathology and immunohistochemistry (IHC) in definitive differentiation, emphasizing the necessity of accurate diagnosis through IHC. Finally, it demonstrates the evolving treatment paradigm from extensive surgery toward a multidisciplinary approach integrating radical resection with adjuvant immunotherapy, reflecting advances in molecular insights and ameliorated outcomes.

Frontiers in OncologyVol. 15
Nanchang University (CN), Second Affiliated Hospital of Nanchang University (CN)
National Natural Science Foundation of China
Openalex Percentile: Top 70%
Cutaneous Melanoma Detection and Management
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