Isowighteone attenuates vascular calcification by targeting HSP90AA1-mediated PI3K-Akt pathway and suppressing osteogenic gene expression
Isowighteone demonstrates significant therapeutic potential by effectively downregulating the expression of osteogenic genes, alleviating vascular calcification, and suppressing the HSP90AA1/PI3K/Akt signaling pathway, thereby improving pathological conditions associated with vascular calcification. These above results not only elucidate isowighteone as a novel therapeutic agent against VC through selective suppression of osteogenic differentiation but also position this phytochemical as a clinically candidate for VC management.
Authors
- Jiahui Peng (ORCID: https://orcid.org/0009-0005-5675-4965)
- Yaoxin Liu (ORCID: https://orcid.org/0000-0002-6103-885X)
- Yuanxi Mo
- Rui Yang (ORCID: https://orcid.org/0000-0003-4405-5882)
- Zhaoyan Xu
- Wanzi Hong
- Qian Huang (ORCID: https://orcid.org/0000-0002-0932-5181)
- An Hye Jin
- Ning Tan (ORCID: https://orcid.org/0009-0001-0589-5822)
- Lei Jiang (ORCID: https://orcid.org/0000-0002-2060-6216)
- Qiqi Song (ORCID: https://orcid.org/0009-0000-8345-1728)
- Yuqi Cheng
- Wing Tak Wong (ORCID: https://orcid.org/0000-0002-4514-3780)
Institutions
- Hong Kong Polytechnic University (HK)
- Hunan University (CN)
- First People's Hospital of Foshan (CN)
- Wuhan Textile University (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-08-20
- DOI
- https://doi.org/10.3389/fbioe.2025.1636883
- Primary Topic
- Phytochemistry and biological activities of Ficus species
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- National Science and Technology Major Project