Multi-omics approaches reveal the mechanisms underlying the interaction between cyst fluid of Echinococcus granulosus and host immune cells
Metabolomics and transcriptomics analyses help identify potential candidate genes and provide diagnostic tools for future research and the discovery of new therapeutic targets. EgCF may regulates the host immune response by up-regulating Th9 cell-related cytokines such as IL-4, TGF-β and IL-9, along with related transcription factors PU.1 and IRF4. This provides a theoretical basis for understanding how <i>Echinococcus granulosus</i> modulates the host immune response and may offer new research avenues for immunoprophylaxis against <i>Echinococcus granulosus</i>.
Authors
- Yuanchun Shi
- Rongdong He (ORCID: https://orcid.org/0000-0003-1670-9332)
- Kalibixiati Aimulajiang (ORCID: https://orcid.org/0000-0003-4491-0359)
- Aili Aierken (ORCID: https://orcid.org/0000-0002-5980-6442)
- Hao Wen (ORCID: https://orcid.org/0000-0001-7144-220X)
- Xue Zhang (ORCID: https://orcid.org/0000-0002-1057-4417)
- Ruofeng Yan
Institutions
- Nanjing Agricultural University (CN)
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- Yili Friendship Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1598028
- Citations
- 3
- Primary Topic
- Parasitic infections in humans and animals
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- National Natural Science Foundation of China