PD-L1+ neutrophils mediate immune regulation of CD8+ T cells in halo nevi
This study is the first to explore the involvement of neutrophils in halo nevi and reveal the potential immunoregulatory role of PD-L1 in this process. The elucidation of this mechanism not only provides a more comprehensive understanding of autoimmune skin diseases but may also offer new strategies for targeted therapy in other related disorders, such as vitiligo.
Authors
- Yixuan Zhang (ORCID: https://orcid.org/0009-0002-8817-1746)
- Yingying Xu (ORCID: https://orcid.org/0000-0003-4924-9379)
- Lu Liu (ORCID: https://orcid.org/0000-0003-0032-9108)
- Haoyang Wang (ORCID: https://orcid.org/0000-0003-2187-9205)
- Wenjun Cui (ORCID: https://orcid.org/0009-0001-2309-1000)
- Min Li (ORCID: https://orcid.org/0000-0001-8786-5629)
Institutions
- Soochow University (CN)
- Suzhou Municipal Hospital (CN)
- Second Affiliated Hospital of Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1628913
- Citations
- 2
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 2.30