Investigating potential biomarkers associated with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis using Mendelian randomization and transcriptomic analysis
PDK4, PPARGC1A, FN1, and PSMB10 were identified as biomarkers causally related to AAV, offering potential for both precise diagnosis and targeted treatment strategies.
Authors
- Kaiqi Huang (ORCID: https://orcid.org/0000-0002-2677-9273)
- Shiwei He (ORCID: https://orcid.org/0000-0002-3817-3869)
- Yanfang Xu (ORCID: https://orcid.org/0000-0002-6207-545X)
- Keng Ye (ORCID: https://orcid.org/0000-0002-3661-3664)
- Zhimin Chen (ORCID: https://orcid.org/0000-0003-2396-9589)
- Yujia Wang (ORCID: https://orcid.org/0000-0001-7197-3596)
- Hong Chen (ORCID: https://orcid.org/0000-0003-2606-0039)
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1186/s13075-025-03630-8
- Citations
- 1
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- National Natural Science Foundation of China
- Fujian Medical University
- Fujian Provincial Health Commission