Comparative analysis of adaptive immunity to SARS-CoV-2 in infected children and adults
While binding and neutralizing antibody levels to SARS-CoV-2 are largely comparable in children and adults, the strength of memory T cell responses induced by infection is reduced in children compared to adults. Adults present heightened cellular memory responses to SARS-CoV-2, but not to seasonal β-coronaviruses HCoV-OC43 and HCoV-HKU1. In contrast, children's T cell memory responses to SARS-CoV-2 closely mirror their response to common seasonal β-coronaviruses.
Authors
- Hélène Decaluwe (ORCID: https://orcid.org/0000-0001-6617-0633)
- Marc‐André Langlois (ORCID: https://orcid.org/0000-0003-4652-3029)
- Roger Zemek (ORCID: https://orcid.org/0000-0001-7807-2459)
- Yannick Galipeau
- Anne Pham‐Huy (ORCID: https://orcid.org/0000-0001-5728-3134)
- Jennifer Bowes (ORCID: https://orcid.org/0000-0002-1000-0245)
- Caroline Quach (ORCID: https://orcid.org/0000-0002-1170-9475)
- Corey Arnold (ORCID: https://orcid.org/0000-0001-6552-6650)
- Benoîte Bourdin (ORCID: https://orcid.org/0000-0003-4714-4696)
- Maala Bhatt (ORCID: https://orcid.org/0000-0003-1265-3482)
- Sabryna Nantel (ORCID: https://orcid.org/0009-0008-0060-4716)
Institutions
- University of Ottawa (CA)
- Children's Hospital of Eastern Ontario (CA)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1038/s41390-025-04256-x
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- University of Ottawa
- Public Health Agency of Canada
- Coalition for Epidemic Preparedness Innovations
- Physicians' Services Incorporated Foundation
- Public Health Agency
- Canadian Institutes of Health Research