Phase 3 Trial of Inhaled Molgramostim in Autoimmune Pulmonary Alveolar Proteinosis
Once-daily inhaled molgramostim led to a greater increase in pulmonary gas transfer than placebo in patients with aPAP. (Funded by Savara; IMPALA-2 ClinicalTrials.gov number, NCT04544293; European Union Clinical Trials Information System number, 2024-511052-41-00.).
Authors
- Yoshikazu Inoue (ORCID: https://orcid.org/0000-0003-3994-874X)
- Elisabeth Bendstrup (ORCID: https://orcid.org/0000-0002-4238-6963)
- Tadahisa Numakura (ORCID: https://orcid.org/0000-0001-9877-6250)
- Ali Ataya (ORCID: https://orcid.org/0000-0001-8505-1680)
- Tisha Wang (ORCID: https://orcid.org/0000-0002-4452-2148)
- Bruce C. Trapnell (ORCID: https://orcid.org/0000-0003-2817-6254)
- Toru Arai (ORCID: https://orcid.org/0000-0002-2222-0683)
- Brenna Carey (ORCID: https://orcid.org/0000-0002-2915-4754)
- Cormac McCarthy (ORCID: https://orcid.org/0000-0003-2896-5210)
- Francesco Bonella (ORCID: https://orcid.org/0000-0001-7579-9767)
- Ross A Arena (ORCID: https://orcid.org/0000-0002-6675-1996)
- Jin Woo Song (ORCID: https://orcid.org/0000-0001-5121-3522)
- Francesca Mariani (ORCID: https://orcid.org/0000-0001-9500-6082)
- Nesrin Moğulkoç (ORCID: https://orcid.org/0000-0003-1870-5669)
- Raymond Pratt (ORCID: https://orcid.org/0000-0002-8143-1106)
- S. Jouneau (ORCID: https://orcid.org/0000-0002-1949-3461)
- Nesrin Öcal (ORCID: https://orcid.org/0000-0002-3789-7769)
- Ilaria Campo (ORCID: https://orcid.org/0000-0002-4423-2482)
- Tomohisa Baba (ORCID: https://orcid.org/0000-0003-4294-634X)
- Rosanna Fleming
- F Mihălţan
- Brian Robinson
- Keiichi Akasaka
- Yasmine Wasfi
Institutions
- Ulsan College (KR)
- Cincinnati Children's Hospital Medical Center (US)
- University of California, Los Angeles (US)
- Cairn University (US)
- Tohoku University (JP)
- Aarhus University (DK)
- Asan Medical Center (KR)
- Aarhus University Hospital (DK)
- University of Florida (US)
- University of Ulsan (KR)
- Ege University (TR)
- Ruhrlandklinik (DE)
- Gülhane Askerî Tıp Akademisi (TR)
- Los Angeles Medical Center (US)
- St. Vincent's University Hospital (IE)
- Institutul de Pneumoftiziologie "Marius Nasta" (RO)
- Sağlık Bilimleri Üniversitesi (TR)
- Kanagawa Cardiovascular and Respiratory Center (JP)
- Saitama Red Cross Hospital (JP)
- Policlinico San Matteo Fondazione (IT)
- Fukujuji Hospital (JP)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Centre Hospitalier Universitaire de Rennes (FR)
- NHO Kinki Chuo Chest Medical Center (JP)
- University of Cincinnati (US)
- University of Health Sciences Antigua (AG)
- University of Cincinnati Medical Center (US)
- Florida College (US)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1056/nejmoa2410542
- Citations
- 9
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 12.15
Funders
- Savara Pharmaceuticals