Decarboxylative Fluorination Catalyzed by Pyridine-Containing Charge-Transfer Complex
Herein, we present a novel organic photoredox decarboxylation system that employs a charge-transfer complex formed between pyridine derivatives and Selectfluor as the catalytic species. Under basic conditions, this system facilitates the decarboxylative fluorination of alkyl carboxylic acids upon visible light irradiation. The methodology applies to primary, secondary, and tertiary carboxylic acids, demonstrating good substrate scope.
Authors
- Yahao Huang (ORCID: https://orcid.org/0009-0005-8872-2845)
- Jinglan Wen
- Zhiyang Ma (ORCID: https://orcid.org/0000-0003-3263-2785)
- Peng Hu (ORCID: https://orcid.org/0000-0001-7864-3514)
- Liang Zhang (ORCID: https://orcid.org/0000-0001-8605-8681)
Institutions
- Institute of Molecular Functional Materials (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1021/acs.orglett.5c03110
- Citations
- 2
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.58
Funders
- National Natural Science Foundation of China
- Guangdong Science and Technology Department
- Guangzhou Municipal Science and Technology Bureau