Front Cover: Luminescent Click‐Pyrenyl Nucleosides: as Novel Building Blocks for Nucleic Acids: Synthesis, Photophysics, Confocal Microscopy Studies, and Oligonucleotide Conjugation (Eur. J. Org. Chem. 29/2025)
The Front Cover shows a luminescent “dinucleoside” synthesized by click reactions. It can be imaged in cancer cells with confocal microscopy or alternatively be conjugated to the 5′-terminus of an oligonucleotide to form a regular B-type DNA duplex after hybridization with the complementary strand. The Research Article by K. Kowalski and co-workers (DOI: 10.1002/ejoc.202500559) highlights how click chemistry provides easy access to a new class of artificial nucleic acid constituents.
Authors
- Natalia Dutkiewicz (ORCID: https://orcid.org/0000-0001-7883-1531)
- Jens Müller (ORCID: https://orcid.org/0000-0003-4713-0606)
- Aleksander Gorski (ORCID: https://orcid.org/0000-0002-5182-5614)
- Damian Trzybiński (ORCID: https://orcid.org/0000-0003-3920-5532)
- Konrad Kowalski (ORCID: https://orcid.org/0000-0003-0600-3205)
- Mateusz Klarek (ORCID: https://orcid.org/0000-0001-9348-4152)
- Magdalena Gapińska (ORCID: https://orcid.org/0000-0002-3125-7920)
- Paweł Hikisz (ORCID: https://orcid.org/0000-0003-2157-2262)
- Krzysztof Woźniak (ORCID: https://orcid.org/0000-0002-0277-294X)
- Tim Schäfer (ORCID: https://orcid.org/0000-0002-4405-1374)
Institutions
- Environmental Protection Agency (US)
- University of Münster (DE)
- Institute of Organic Chemistry (PL)
- Institute of Physical Chemistry (PL)
- Environmental Protection Agency (IE)
- University of Warsaw (PL)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1002/ejoc.70033
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00