CDK4/6 inhibitors synergize with radiotherapy to prime the tumor microenvironment and enhance the antitumor effect of anti-PD-L1 immunotherapy in triple-negative breast cancer
Combining CDK4/6 inhibitors with RT enhanced the antitumor effects of aPD-L1 immunotherapy against TNBC. This effect was correlated with increased IFN-γ secretion and recruitment of CD4 + and CD8 + T cells and M1 tumor-associated macrophages, leading to modulation of the tumor microenvironment.
Authors
- Chiun‐Sheng Huang (ORCID: https://orcid.org/0000-0002-6557-211X)
- Ying‐Chun Shen (ORCID: https://orcid.org/0000-0001-8426-9071)
- Sung‐Hsin Kuo (ORCID: https://orcid.org/0000-0003-0054-887X)
- Wen-Chi Yang (ORCID: https://orcid.org/0000-0002-0949-7370)
- Ming‐Feng Wei (ORCID: https://orcid.org/0000-0002-1796-1049)
Institutions
- National Taiwan University of Science and Technology (TW)
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1186/s12929-025-01173-3
- Citations
- 2
- Primary Topic
- Advanced Breast Cancer Therapies
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Taiwan University Hospital
- National Taiwan University
- National Science and Technology Council