Circulating miRNAs as potential liquid biomarkers for pediatric gliomas

This study demonstrates the potential of circulating miRNAs as valuable biomarkers for pediatric glioma detection and monitoring. Five examined circulating miRNAs were differentially expressed in pediatric glioma patients compared to controls. These miRNAs were correlated with glioma and could distinguish healthy from gliomas patients. Statistical analysis suggested these miRNAs may also distinguish between various glioma subtypes. Inhibition of the most promising circulating miRNA, miR-182-5p, decreased migration ability and invasiveness of pediatric high-grade glioma IV cells. In the future, the miRNAs studied could have applications as biomarkers for clinical management and treatment targets.