Prediction of silica nanoparticle biodistribution using a calibrated physiologically based model: Unbound fraction and elimination rate constants for the kidneys and phagocytosis identified as major determinants
The mPBPK model effectively predicts the pharmacokinetics of diverse SiNPs, offering insights to optimize nanoparticle-based drug delivery systems and facilitating their translation from preclinical models to clinical applications.
Authors
- Hamidreza Ghandehari (ORCID: https://orcid.org/0000-0002-9333-9964)
- Madison Parrot (ORCID: https://orcid.org/0009-0005-3888-2760)
- Prashant Dogra (ORCID: https://orcid.org/0000-0001-6722-7371)
- Venkata Yellepeddi (ORCID: https://orcid.org/0000-0003-3819-9054)
- María J. Peláez (ORCID: https://orcid.org/0000-0003-2859-0762)
- Joseph Cave (ORCID: https://orcid.org/0000-0002-0177-875X)
Publication Details
- Journal
- International Journal of Clinical Pharmacology and Therapeutics
- Published
- 2025-08-20
- DOI
- https://doi.org/10.5414/cp204837
- Citations
- 1
- Primary Topic
- Nanoparticles: synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.52