A New Lignan with Potential Anti-inflammatory Activity from Notopterygium incisum
Notopterygium incisum is widely used in clinical practice because of its complex chemical composition and remarkable pharmacological effects.In this study, a previously undescribed lignan (1) was isolated from N. incisum.Its structure was evaluated through examinations of the NMR, HREIMS data and ECD calculation.Compound 1 demonstrated significant anti-inflammatory potential by inhibiting the secretion of nitric oxide (NO) in lipopolysaccharide (LPS)-induced macrophages, with an IC50 value of 3.57 M.
Authors
- Da‐Le Guo (ORCID: https://orcid.org/0000-0003-3219-7066)
- Lijun Huang (ORCID: https://orcid.org/0000-0001-9673-3628)
- Yun Deng (ORCID: https://orcid.org/0000-0002-3428-8992)
- Lei Zhao (ORCID: https://orcid.org/0000-0002-1779-4711)
- Xinyu Li (ORCID: https://orcid.org/0000-0002-5908-6676)
- Su Hu
Publication Details
- Journal
- Records of Natural Products
- Published
- 2025-08-20
- DOI
- https://doi.org/10.25135/rnp.2505.3518
- Primary Topic
- Plant-derived Lignans Synthesis and Bioactivity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China