Palladium-Catalyzed Carbonylative Fluoroalkylation of 1,3-Enynes to Access Allenyl Primary Amides
A palladium-catalyzed difunctional fluoroalkylative carbonylation of 1,3-enynes with fluoroalkyl halides and ammonium iodide has been developed, providing rapid access to fluoroalkylated allenyl primary amides with a broad substrate scope, high chemo- and regioselectivity, and good functional group tolerance.
Authors
- Xiao‐Feng Wu (ORCID: https://orcid.org/0000-0001-6622-3328)
- Zhipeng Bao (ORCID: https://orcid.org/0000-0001-8376-1195)
- A Ru‐Han
- Chang‐Sheng Kuai (ORCID: https://orcid.org/0000-0002-6354-1117)
Institutions
- Dalian Institute of Chemical Physics (CN)
- Chinese Academy of Sciences (CN)
- Leibniz Institute for Catalysis (DE)
- Dalian National Laboratory for Clean Energy (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1021/acs.orglett.5c03213
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Dalian Institute of Chemical Physics
- National Key Research and Development Program of China