Focal lymphovascular space invasion: Friend or foe? A large retrospective analysis on stage I endometrioid endometrial carcinomas
In stage I endometrioid ECs, LVSI-focal was not associated with reduced oncologic outcomes compared to LVSI-negative. In contrast, LVSI-substantial was associated with aggressive clinicopathologic and molecular features and behaved as an independent prognostic factor for reduced survival. Our results were further confirmed in two low-risk EC settings: grade 1-2 with myometrial infiltration, and the MMRp-ERpos group.
Authors
- Giovanni Esposito
- Emilia Palmieri (ORCID: https://orcid.org/0000-0002-6566-2502)
- Angela Santoro (ORCID: https://orcid.org/0000-0002-6964-5152)
- Lucia Tortorella (ORCID: https://orcid.org/0000-0001-5271-3051)
- Ilaria Capasso (ORCID: https://orcid.org/0000-0001-5987-6654)
- Gian Franco Zannoni (ORCID: https://orcid.org/0000-0002-4473-7560)
- Emanuele Perrone (ORCID: https://orcid.org/0000-0002-0938-2493)
- Matteo Loverro (ORCID: https://orcid.org/0000-0002-9740-3169)
- Andrea Mariani
- Camilla Nero (ORCID: https://orcid.org/0000-0002-4442-4046)
- Diana Giannarelli (ORCID: https://orcid.org/0000-0002-6085-1195)
- Francesco Fanfani (ORCID: https://orcid.org/0000-0002-4354-5735)
- Anna Fagotti (ORCID: https://orcid.org/0000-0002-0465-5990)
- F Salvati
- Fulvia Pirrelli
- Alessia Fossatelli
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Agostino Gemelli University Polyclinic (IT)
- Mayo Clinic in Arizona (US)
Publication Details
- Journal
- European Journal of Cancer
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1016/j.ejca.2025.115736
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00