Current Use and Complications Associated With Bone Morphogenetic Protein in Spine Fusion Surgery
We found that rhBMP-2 was used extensively in AL/TF and LLIF, frequently in PCF and PL/TF, occasionally in TLIF, and sparingly in ACF. While patterns of use differed in the cervical spine, mostly selecting for patients with risk factors for pseudarthrosis, this pattern of usage was only found in posterior lumbar and thoracic fusion. There was no obvious trend in complications associated with rhBMP-2 use.
Authors
- Kyle W. Morse (ORCID: https://orcid.org/0000-0001-9136-8078)
- Tomoyuki Asada (ORCID: https://orcid.org/0000-0003-3470-5546)
- Matthew E. Cunningham (ORCID: https://orcid.org/0000-0003-3723-062X)
- Todd J. Albert (ORCID: https://orcid.org/0000-0002-4287-1512)
- Evan Sheha (ORCID: https://orcid.org/0000-0003-4339-6079)
- Francis Lovecchio (ORCID: https://orcid.org/0000-0001-5236-1420)
- James Dowdell (ORCID: https://orcid.org/0000-0001-9852-4133)
- Sheeraz A. Qureshi (ORCID: https://orcid.org/0000-0002-7177-1756)
- James M. Farmer
- Maximilian Korsun (ORCID: https://orcid.org/0000-0001-7289-7564)
- Takashi Hirase (ORCID: https://orcid.org/0000-0001-6476-6548)
- Cole Kwas (ORCID: https://orcid.org/0009-0002-4156-522X)
- Bo Zhang (ORCID: https://orcid.org/0000-0002-0607-6044)
- Eric S. Kim (ORCID: https://orcid.org/0000-0002-1065-2876)
- Joshua Zhang (ORCID: https://orcid.org/0009-0000-0023-6329)
- Russel C. Huang
- Harvinder S. Sandhu (ORCID: https://orcid.org/0000-0003-2013-1828)
- Han Jo Kim
Institutions
- Tufts University (US)
- Hospital for Special Surgery (US)
- Globus Medical (United States) (US)
- International Society for the Advancement of Spine Surgery
- Stryker (United States) (US)
Publication Details
- Journal
- Spine
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1097/brs.0000000000005372
- Primary Topic
- Orthopaedic implants and arthroplasty
- Type
- article
- Field-Weighted Citation Impact
- 0.00