Brain Endothelial Soluble <scp>ST2</scp> Production and Cerebral Edema in a Rat Model of Ischemic Stroke
Plasma sST2 level is associated with edema, functional outcome, and mortality after ischemic stroke. Knockout of sST2 reduced post-stroke cerebral edema and was associated with increased staining for the tight junction protein ZO-1. These findings establish a mechanistic link between sST2 and brain edema and highlight its potential as a future therapeutic target. ANN NEUROL 2026;99:134-147.
Authors
- Elle Fietsam
- Animesh Acharjee (ORCID: https://orcid.org/0000-0003-2735-7010)
- Brian L. Edlow (ORCID: https://orcid.org/0000-0001-7235-8456)
- David Y. Chung (ORCID: https://orcid.org/0000-0002-7149-5851)
- Tracy L. Young‐Pearse (ORCID: https://orcid.org/0000-0001-7846-1542)
- Matthew B. Bevers (ORCID: https://orcid.org/0000-0003-0878-8464)
- Cenk Ayata (ORCID: https://orcid.org/0000-0002-3644-6042)
- Caroline Booraem (ORCID: https://orcid.org/0009-0000-3294-6253)
- Kellianne D. Alexander (ORCID: https://orcid.org/0000-0002-4572-2600)
- Kazutaka Sugimoto (ORCID: https://orcid.org/0000-0002-7666-2620)
- Jiaqi An (ORCID: https://orcid.org/0000-0003-0272-0514)
- Karen Li (ORCID: https://orcid.org/0000-0002-0261-743X)
- Arum Yoo (ORCID: https://orcid.org/0000-0002-2685-1335)
- Cristina Sastre (ORCID: https://orcid.org/0000-0001-9132-2870)
- W. Taylor Kimberly (ORCID: https://orcid.org/0000-0002-2519-8530)
- Divya Reddy
Institutions
- Brigham and Women's Hospital (US)
- Sun Yat-sen University (CN)
- Yamaguchi University (JP)
- Massachusetts General Hospital (US)
- Center for Neuro-Oncology (US)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Cancer Research UK Clinical Trials Unit (GB)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1002/ana.78006
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- National Institutes of Health