SIRT3 attenuates sepsis-induced EndMT and cardiac remodeling by facilitating mitophagy process via PINK1/Parkin signaling
Our findings suggest that SIRT3 suppresses EndMT-mediated cardiac fibrosis by promoting PINK1/Parkin-dependent mitophagy, offering novel insights for the treatment of SIMI.
Authors
- Aizhong Wang (ORCID: https://orcid.org/0000-0003-4524-4319)
- Derong Cui (ORCID: https://orcid.org/0000-0002-0369-3899)
- Yujun Luo (ORCID: https://orcid.org/0000-0002-5149-6451)
- Jieqiong Meng
- Penghao Liu (ORCID: https://orcid.org/0000-0002-9100-1580)
- Tianhua Xu (ORCID: https://orcid.org/0000-0003-4831-0609)
Institutions
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Zhongshan Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1016/j.intimp.2025.115377
- Citations
- 6
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 8.13
Funders
- National Natural Science Foundation of China