Transcriptome profiling by RNA sequencing reveals novel targets of Gemini nano curcumin on p53-mutant HT-29 colorectal cancer cells
Our data reveal that nanocurcumin might affects HT-29 colorectal cancer cells through modulating different pathways such as endoplasmic reticulum response, and transporter-related genes. More studies necessitate to unravel the molecular mechanisms and proteins involved in these pathways that could be considered as novel therapeutic targets in colorectal cancer.
Authors
- Esmaeil Babaei
- Roxana Karimzadeh
- Hewa Jalal Azeez (ORCID: https://orcid.org/0000-0002-2513-8263)
Institutions
- University of Tabriz (IR)
- Farabi Hastanesi (TR)
Publication Details
- Journal
- Journal of Genetic Engineering and Biotechnology
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1016/j.jgeb.2025.100548
- Citations
- 1
- Primary Topic
- Curcumin's Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.59