Neoadjuvant Chemotherapy is Associated with Worse 5-Year Overall Survival in Patients with Metaplastic Breast Cancer Compared with Primary Surgery: A National Cancer Database Analysis
NACT was associated with worse OS in MpBC, likely due to its chemotherapy-resistant biology and low pCR rate. For patients with resectable MpBC, upfront surgery and adjuvant chemotherapy and radiation may offer better outcomes. Further research is needed to clarify the role of immunotherapy and advance systemic treatment strategies.
Authors
- Azka Ali (ORCID: https://orcid.org/0000-0001-7476-6664)
- Mari Nelis (ORCID: https://orcid.org/0000-0001-9748-1020)
- Zahraa Al‐Hilli (ORCID: https://orcid.org/0000-0003-2383-0499)
- Lauren Kopicky
- Anna Chichura (ORCID: https://orcid.org/0000-0003-0768-4858)
- Rahul D. Tendulkar (ORCID: https://orcid.org/0000-0002-6633-0577)
- Wei Wei (ORCID: https://orcid.org/0000-0002-0960-7269)
- Xiaoying Chen (ORCID: https://orcid.org/0000-0002-6710-3798)
Institutions
- Cleveland Clinic (US)
- University of Illinois Chicago (US)
- University of Chicago (US)
Publication Details
- Journal
- Annals of Surgical Oncology
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1245/s10434-025-18085-z
- Citations
- 1
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.94