Interaction between coffee consumption and polygenic risk score in relation to diabetes: insights from the Maastricht study
No significant interaction was observed between coffee consumption and PRS for prediabetes and T2DM. Coffee consumption was associated with the prevalence of both conditions in a pattern that may be U-shaped. However, these associations appear to be population-specific and require validation in diverse populations to clarify gene-lifestyle interactions.
Authors
- Anke Wesselius (ORCID: https://orcid.org/0000-0003-4474-9665)
- Tos T. J. M. Berendschot (ORCID: https://orcid.org/0000-0002-8101-939X)
- Marleen M. J. van Greevenbroek (ORCID: https://orcid.org/0000-0002-2989-1631)
- Yi Rao (ORCID: https://orcid.org/0000-0002-0405-5426)
- Yingfen Qin (ORCID: https://orcid.org/0000-0002-8456-1678)
- Hans Bosma (ORCID: https://orcid.org/0000-0003-4333-4564)
- Maurice Petrus Zeegers (ORCID: https://orcid.org/0000-0002-2387-083X)
- Bastiaan E. de Galan (ORCID: https://orcid.org/0000-0002-1255-7741)
- Carla Kallen (ORCID: https://orcid.org/0000-0003-1468-8793)
- Annemarie Koster (ORCID: https://orcid.org/0000-0003-1583-7391)
- Simone J. P. M. Eussen (ORCID: https://orcid.org/0000-0003-0559-6838)
- Yiming Chen (ORCID: https://orcid.org/0000-0003-1211-4366)
- Tsui-Fang Lin
- Evan Yi-Wen Yu (ORCID: https://orcid.org/0000-0001-7825-5087)
Institutions
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- Maastricht University (NL)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Southeast University (CN)
- KU Leuven (BE)
Publication Details
- Journal
- European Journal of Nutrition
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1007/s00394-025-03782-y
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sanofi
- Health Foundation Limburg
- Novo Nordisk
- Southeast University
- Stichting De Weijerhorst
- European Regional Development Fund
- CARIM School for Cardiovascular Diseases, Universiteit Maastricht
- Care and Public Health Research Institute, Universiteit Maastricht
- Fundamental Research Funds for the Central Universities
- NUTRIM School of Nutrition and Translational Research in Metabolism
- Cilag