Multitarget 8-methoxypsoralens against Alzheimer’s disease: extraction, synthesis, <i>in vitro</i> and <i>in silico</i> studies
Among the synthesized compounds, <b>3d</b> and <b>3e</b> demonstrated significant inhibitory effects against the chosen targets, exhibiting IC<sub>50</sub> values between 5.8 ± 0.13 μM and 13 ± 0.12 μM. Furthermore, the docking experiments showed important binding interactions of these compounds with BACE1, AChE, and BuChE. The study demonstrates the potential of 8-MOP derivatives for targeting AD drug targets.
Authors
- Vaibhav Gandhi (ORCID: https://orcid.org/0000-0003-1121-7419)
- Uma Agarwal (ORCID: https://orcid.org/0000-0003-4821-4430)
- Vaishali M. Patil (ORCID: https://orcid.org/0000-0002-5352-7872)
- Saroj Verma (ORCID: https://orcid.org/0000-0002-7298-3355)
- Rajiv Kumar Tonk (ORCID: https://orcid.org/0000-0002-0842-5121)
Institutions
- Chaudhary Charan Singh University (IN)
- Delhi Pharmaceutical Science and Research University (IN)
- KR Mangalam University (IN)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1080/17568919.2025.2546776
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00