Hybrid molecule SA-10 and its PLGA nanosuspension protect human and rodent retinal ganglion cells against neuronal injury
SA-10 demonstrated significant ROS reduction and preserved RGC survival and function in both I/R mouse models and HREs, with immunohistochemistry confirming upregulation of Hmox1 and downregulation of TNF-α in the SA-10-NP-treated group. SA-10-NP provided sustained drug delivery and bioavailability, showcasing strong neuroprotective effects and offering a potential therapeutic strategy for glaucomatous optic neuropathy and other neurodegenerative conditions.
Authors
- Tuyen Bui (ORCID: https://orcid.org/0000-0001-8509-3653)
- Dorota L. Stankowska (ORCID: https://orcid.org/0000-0002-2541-6649)
- Suchismita Acharya
- Bindu Kodati (ORCID: https://orcid.org/0000-0002-4956-841X)
- Charles E. Amankwa (ORCID: https://orcid.org/0000-0002-1120-7053)
- Biddut DebNath
- Jennifer H. Pham (ORCID: https://orcid.org/0000-0003-0965-3625)
- Brad D. Hatfield
- Gretchen A. Johnson (ORCID: https://orcid.org/0000-0001-7330-269X)
- Wei Zhang
- Raghu R. Krishnamoorthy (ORCID: https://orcid.org/0000-0001-7278-4324)
- Komarova Le (ORCID: https://orcid.org/0009-0008-0618-2358)
- Joel Gutiérrez
- Rojan Satyal
- Ella R. Sinnott
- Rachel Y. Gitter
Institutions
- Texas Tech University (US)
- University of North Texas (US)
- The University of Texas at El Paso (US)
- University of North Texas Health Science Center (US)
- The University of Texas at Arlington (US)
- George Washington University (US)
- Texas College (US)
- Smith-Kettlewell Eye Research Institute (US)
Publication Details
- Journal
- BMC Neuroscience
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1186/s12868-025-00971-7
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Eye Institute