Evolution and Co-occurrence of PI3K Pathway Gene Mutations in Endometrial Carcinoma Molecular Subtypes at the Single-Cell Level
Our exploratory, hypothesis-generating analysis suggests that PI3K pathway alterations evolve distinctly in MMRd/POLE compared with NSMP EECs, which may have therapeutic consequences. Further studies on the signaling output and PI3K pathway inhibitor response in EECs with subclonal PI3K pathway alterations are warranted.
Authors
- Nadeem R. Abu‐Rustum (ORCID: https://orcid.org/0000-0001-9689-1298)
- Fresia Pareja (ORCID: https://orcid.org/0000-0003-3748-8049)
- Pier Selenica (ORCID: https://orcid.org/0000-0003-0086-0513)
- Nadeem Riaz (ORCID: https://orcid.org/0000-0001-9873-5862)
- Britta Weigelt (ORCID: https://orcid.org/0000-0001-9927-1270)
- Sarat Chandarlapaty (ORCID: https://orcid.org/0000-0003-4532-8053)
- Edaise M. da Silva (ORCID: https://orcid.org/0000-0003-3281-7333)
- David N. Brown (ORCID: https://orcid.org/0000-0002-8249-3632)
- Shirin Issa Bhaloo (ORCID: https://orcid.org/0000-0001-9765-8711)
- Timothy Hoang (ORCID: https://orcid.org/0000-0002-3012-3461)
- Arnaud Da Cruz Paula (ORCID: https://orcid.org/0000-0001-7694-8760)
- Jorge S. Reis‐Filho (ORCID: https://orcid.org/0000-0003-2969-3173)
- Higinio Dopeso (ORCID: https://orcid.org/0000-0003-0060-1861)
- Thais Basili (ORCID: https://orcid.org/0000-0003-3216-3544)
- Yingjie Zhu (ORCID: https://orcid.org/0000-0003-1849-6019)
- Hunter Green (ORCID: https://orcid.org/0009-0002-3944-6803)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- AstraZeneca (United States) (US)
- i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto (PT)
- Quest Diagnostics (United States) (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-1237
- Citations
- 1
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81