The Impact of Concordance between Liquid and Tissue Biopsy for Actionable Mutations: Insights from the ROME Trial
The study highlights the potential value of integrating both biopsy modalities in selected clinical contexts. See related commentary by Saldanha and Siu, p. 7.
Authors
- Federico Cappuzzo (ORCID: https://orcid.org/0000-0002-6295-6767)
- Giuseppe Curigliano (ORCID: https://orcid.org/0000-0003-1781-2518)
- Stefano Tamberi (ORCID: https://orcid.org/0000-0002-7087-9116)
- Roberto Bordonaro (ORCID: https://orcid.org/0000-0001-5005-0880)
- Mauro Biffoni (ORCID: https://orcid.org/0000-0002-1304-9060)
- Fabio Puglisi (ORCID: https://orcid.org/0000-0003-0573-4938)
- Giuseppe Giannini (ORCID: https://orcid.org/0000-0003-0299-4056)
- Elisabetta Fenocchio (ORCID: https://orcid.org/0000-0001-6679-0955)
- Umberto Malapelle (ORCID: https://orcid.org/0000-0003-3211-9957)
- Bruna Cerbelli (ORCID: https://orcid.org/0000-0001-5419-2309)
- Stefania Gori (ORCID: https://orcid.org/0000-0001-6320-405X)
- Agnese Fabbri (ORCID: https://orcid.org/0000-0002-3357-6343)
- Andrea Botticelli (ORCID: https://orcid.org/0000-0002-6425-9893)
- Federica Mazzuca (ORCID: https://orcid.org/0000-0002-6580-286X)
- Simona Pisegna (ORCID: https://orcid.org/0000-0002-6910-9528)
- Paolo A. Ascierto (ORCID: https://orcid.org/0000-0002-8322-475X)
- Alberto Zambelli (ORCID: https://orcid.org/0000-0002-1374-1831)
- Valentina Guarneri (ORCID: https://orcid.org/0000-0002-2375-8397)
- Giulio Metro (ORCID: https://orcid.org/0000-0002-4978-9212)
- Pierfranco Conté (ORCID: https://orcid.org/0000-0002-5210-5344)
- Maurizio Simmaco (ORCID: https://orcid.org/0000-0003-4164-1472)
- Simone Scagnoli (ORCID: https://orcid.org/0000-0003-4943-5622)
- Lorenzo Fornaro (ORCID: https://orcid.org/0000-0002-0187-5904)
- Edoardo Crimini (ORCID: https://orcid.org/0000-0002-1869-0607)
- Paolo Marchetti (ORCID: https://orcid.org/0000-0002-9064-8761)
- Giovanni Blandino (ORCID: https://orcid.org/0000-0002-6970-2241)
- Donatella Marino (ORCID: https://orcid.org/0000-0001-6565-0870)
- Sara Lonardi (ORCID: https://orcid.org/0000-0002-7593-8138)
- Maurizio Ceracchi (ORCID: https://orcid.org/0000-0003-1877-9238)
- Daniele Pozzessere (ORCID: https://orcid.org/0000-0002-6344-7630)
- Massimo Aglietta (ORCID: https://orcid.org/0000-0002-2255-7972)
- Giulia d’Amati (ORCID: https://orcid.org/0000-0002-6959-691X)
- Giuseppe Tonini (ORCID: https://orcid.org/0000-0003-4442-8677)
- Sergio Bracarda (ORCID: https://orcid.org/0000-0002-0703-2959)
- Sofia Verkhovskaia (ORCID: https://orcid.org/0009-0008-2599-807X)
- Andrea DeCensi (ORCID: https://orcid.org/0000-0003-2635-4491)
- Marianna Nuti (ORCID: https://orcid.org/0000-0003-1809-1003)
- Ugo De Giorgi (ORCID: https://orcid.org/0000-0001-7520-2908)
- Giancarlo Pruneri (ORCID: https://orcid.org/0000-0002-7963-7172)
- Lucia Del Mastro (ORCID: https://orcid.org/0000-0002-9546-5841)
- Annamaria Pessino (ORCID: https://orcid.org/0000-0001-8040-378X)
- Chiara Cremolini (ORCID: https://orcid.org/0000-0002-0520-4841)
- Lidia Strigari (ORCID: https://orcid.org/0000-0003-4293-2298)
- Giovanni Butturini (ORCID: https://orcid.org/0000-0002-9172-4885)
- Ettore Capoluongo (ORCID: https://orcid.org/0000-0002-5647-4059)
- Nello Martini
Institutions
- University of Pisa (IT)
- University of Verona (IT)
- University of Udine (IT)
- Istituto Nazionale di Statistica (IT)
- University of Padua (IT)
- Università Campus Bio-Medico (IT)
- University of Milan (IT)
- University of Perugia (IT)
- Istituto Superiore di Sanità (IT)
- Fondazione Roma (IT)
- Policlinico Umberto I (IT)
- Ente Ospedaliero Ospedali Galliera (IT)
- Associazione Italiana Sclerosi Multipla (IT)
- Azienda Ospedaliera di Perugia (IT)
- Rete Europea Dell’Innovazione (Italy) (IT)
- Fondazione Crui (IT)
- Ospedale "Santa Maria delle Croci" di Ravenna (IT)
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- Ospedale Sacro Cuore Don Calabria (IT)
- Advanced Computer System (Italy) (IT)
- Ospedale Garibaldi (IT)
- Ospedale Papa Giovanni XXIII (IT)
- Istituto Oncologico Veneto (IT)
- Ospedale Santa Maria (IT)
- Istituto Dermopatico dell'Immacolata (IT)
- CTO Andrea Alesini (IT)
- Federico II University Hospital (IT)
- Azienda USL di Bologna (IT)
- National Institute of Health (AM)
- Ospedale per gli Infermi (IT)
- Azienda Ospedaliera S.Maria (IT)
- National Cancer Institute (UA)
- Azienda Ospedaliera Sant'Andrea (IT)
- Ospedale di Belcolle (IT)
- Department of Medical Sciences (BY)
- A. O. Ordine Mauriziano di Torino (IT)
- IRCCS San Camillo Hospital (IT)
- National Cancer Institute (MY)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- Campus Bio Medico University Hospital (IT)
- Tumori Foundation (US)
- Ospedale Policlinico San Martino (IT)
- Candiolo Cancer Institute (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto Pasteur (IT)
- Ospedale di Prato Santo Stefano (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- IRCCS Humanitas Research Hospital (IT)
- Azienda Ospedaliera Universitaria Pisana (IT)
- European Institute of Oncology (IT)
- University of Milano-Bicocca (IT)
- University of Naples Federico II (IT)
- University of Genoa (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-0430
- Citations
- 3
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Amgen
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Sanofi
- Gilead Sciences
- Celgene
- Merck KGaA
- Novocure
- Les Laboratories Pierre Fabre
- BeiGene
- Incyte
- Galecto
- Seagen
- Eisai
- Istituto Superiore di Sanità
- Astellas Pharma
- Servier
- PharmaMar
- Ipsen
- Italfarmaco
- Agenzia Italiana del Farmaco, Ministero della Salute
- Daiichi Sankyo Europe