Mendelian randomization study of self-reported long sleep duration, short sleep duration, and insomnia and cognitive function

This study suggests self-reported short sleep duration was causally associated with cognitive decline and self-reported insomnia was causally associated with increased risk of Alzheimer's disease in individuals of European ancestry. The evidence of causality between long sleep duration and cognitive function requires further investigation. These results may have implications for public health interventions aimed at reducing the risk of cognitive decline.

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Publication Details

Journal
PLoS ONE
Published
2025-08-20
DOI
https://doi.org/10.1371/journal.pone.0330782
Primary Topic
Sleep and related disorders
Type
article
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article

Mendelian randomization study of self-reported long sleep duration, short sleep duration, and insomnia and cognitive function

Yunyun Guo
1 links
PLoS ONE
Sleep and related disorders
article

Mendelian randomization study of self-reported long sleep duration, short sleep duration, and insomnia and cognitive function

Yunyun Guo
article en

Abstract

This study suggests self-reported short sleep duration was causally associated with cognitive decline and self-reported insomnia was causally associated with increased risk of Alzheimer's disease in individuals of European ancestry. The evidence of causality between long sleep duration and cognitive function requires further investigation. These results may have implications for public health interventions aimed at reducing the risk of cognitive decline.

PLoS ONEVol. 20(8)
Imperial College London (GB)
Openalex Percentile: Top 78%
Sleep and related disorders
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