Effect of Midazolam Premedication on Salivary Cortisol Levels in Pediatric Patients with Negative Frankl Behavior: A Pilot Study
These preliminary findings suggest that Midazolam-based management in children with definitely negative behavior may be associated with reduced physiological stress responses. As a pilot study with a limited sample and inherent group-allocation bias, the results should be interpreted with caution. The methodology proved feasible and supports the use of salivary cortisol in future, larger-scale studies designed to disentangle behavioral and pharmacological effects.
Authors
- Esther García Miralles (ORCID: https://orcid.org/0000-0001-8864-3702)
- Isabel Torres-Cuevas (ORCID: https://orcid.org/0000-0002-8098-1106)
- Clara Guinot‐Barona (ORCID: https://orcid.org/0000-0001-8841-7975)
- Laura Marqués Martínez (ORCID: https://orcid.org/0000-0001-5722-0547)
- Juan Ignacio Aura‐Tormos (ORCID: https://orcid.org/0000-0002-0054-1005)
- Bianca Quartararo
Institutions
- Universitat de València (ES)
- Valencia Catholic University Saint Vincent Martyr (ES)
Publication Details
- Journal
- Children
- Published
- 2025-08-20
- DOI
- https://doi.org/10.3390/children12081097
- Primary Topic
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitat de València
- Universidad Católica de Valencia San Vicente Màrtir