Is 2nd JAKi treatment for UC worth the effort? A retrospective, multi-centre UK study
In this highly refractory cohort with active UC a second JAKi effectively achieved remission following IR to first JAKi. Type of first JAKi failure did not appear to influence clinical remission. No new safety signals were found.
Authors
- Rohith Kumar
- Christopher A Lamb (ORCID: https://orcid.org/0000-0002-7271-4956)
- Christian Selinger (ORCID: https://orcid.org/0000-0002-4361-549X)
- Lucy Hicks (ORCID: https://orcid.org/0000-0002-3065-1635)
- Chirag Patel (ORCID: https://orcid.org/0000-0001-8280-1140)
- Chaonan Dong
- Yaa Danso (ORCID: https://orcid.org/0009-0009-8572-131X)
- Emma L. Davis (ORCID: https://orcid.org/0000-0001-6261-775X)
- Anjan Dhar (ORCID: https://orcid.org/0000-0001-8964-2031)
- Maria Bishara
- Chandni Radia (ORCID: https://orcid.org/0009-0002-1572-2172)
- Aileen Fraser (ORCID: https://orcid.org/0000-0001-6462-5091)
- Paul Harrow
- Mohammed Allah-Ditta
- Mark Samaan (ORCID: https://orcid.org/0000-0002-4057-9200)
- Lushen Pillay (ORCID: https://orcid.org/0000-0001-5132-9955)
- Xin Yi Choon
- Philip Harvey (ORCID: https://orcid.org/0000-0002-1192-9910)
- Klaartje Bel Kok (ORCID: https://orcid.org/0000-0002-5942-9149)
- Nicholas Burr (ORCID: https://orcid.org/0000-0003-1988-2982)
- Alexander T. Elford (ORCID: https://orcid.org/0000-0001-6144-1369)
- Konstantina Rosiou (ORCID: https://orcid.org/0000-0001-7260-1866)
- Muhammad Azhar Hussain (ORCID: https://orcid.org/0000-0001-7308-9235)
- Megan Rawcliffe
- Tim Raine (ORCID: https://orcid.org/0000-0002-5855-9873)
- Jie Han Yeo (ORCID: https://orcid.org/0000-0003-0256-6895)
- Fiona Rees (ORCID: https://orcid.org/0009-0003-7637-1166)
- Rachel Cooney (ORCID: https://orcid.org/0000-0003-3710-157X)
- Puneet Chhabra (ORCID: https://orcid.org/0000-0002-1708-0196)
- Alexandra Kent (ORCID: https://orcid.org/0000-0003-0577-6177)
- Katie Yeung (ORCID: https://orcid.org/0000-0003-3629-9131)
- Polychronis Pavlidis (ORCID: https://orcid.org/0000-0003-4864-2208)
- Sara McCartney (ORCID: https://orcid.org/0000-0003-2438-6086)
- Ally Speight (ORCID: https://orcid.org/0000-0003-3184-9181)
- Charlie W. Lees (ORCID: https://orcid.org/0000-0002-0732-8215)
- Jens Toft
- Kamal Patel (ORCID: https://orcid.org/0000-0002-8114-2283)
- Alissa J. Walsh (ORCID: https://orcid.org/0000-0002-8994-1186)
- Jimmy K. Limdi (ORCID: https://orcid.org/0000-0002-1039-6251)
- Dania Al-Zarrad
- Hannah Trodden-Mittnacht
- Karishma Sethi-Arora
- Emma Johnston (ORCID: https://orcid.org/0009-0008-0294-2137)
- Tariq Ahmad
- Krishna Shah
- Susan Ritchie
- Roisin Campbell
- Melissa F Hale
- Becky George
- Alice Hewitt
- Nitish Jivan Sawan
- Ruth Rudling
- Sonia Kalyanji
Institutions
- University of Wolverhampton (GB)
- University of Leeds (GB)
- University Hospitals Birmingham NHS Foundation Trust (GB)
- University College London Hospitals NHS Foundation Trust (GB)
- Imperial College Healthcare NHS Trust (GB)
- The University of Melbourne (AU)
- King's College London (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Barts Health NHS Trust (GB)
- University of Exeter (GB)
- Leeds Teaching Hospitals NHS Trust (GB)
- Royal Devon & Exeter NHS Foundation Trust (GB)
- County Durham and Darlington NHS Foundation Trust (GB)
- Western General Hospital (GB)
- University Hospitals Bristol NHS Foundation Trust (GB)
- Salford Royal NHS Foundation Trust (GB)
- St George’s University Hospitals NHS Foundation Trust (GB)
- West Middlesex University Hospital (GB)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Edinburgh Cancer Research (GB)
- John Radcliffe Hospital (GB)
- Calderdale and Huddersfield NHS Foundation Trust (GB)
- Queen Elizabeth Hospital (GB)
- Sheffield Teaching Hospitals NHS Foundation Trust (GB)
- King's College Hospital NHS Foundation Trust (GB)
- St. Thomas Hospital (CA)
- Weston Area Health NHS Trust (GB)
- University Hospitals Sussex NHS Foundation Trust (GB)
- Torbay and South Devon NHS Foundation Trust (GB)
- The Royal Wolverhampton NHS Trust (GB)
- Wolverhampton Hospital (GB)
- Queen Elizabeth University Hospital (GB)
- Mid Yorkshire Hospitals NHS Trust (GB)
- St Mark's Hospital (GB)
- University College London (GB)
- Newcastle University (GB)
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1093/ecco-jcc/jjaf154
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.82