Is 2nd JAKi treatment for UC worth the effort? A retrospective, multi-centre UK study

In this highly refractory cohort with active UC a second JAKi effectively achieved remission following IR to first JAKi. Type of first JAKi failure did not appear to influence clinical remission. No new safety signals were found.

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Publication Details

Journal
Journal of Crohn s and Colitis
Published
2025-08-18
DOI
https://doi.org/10.1093/ecco-jcc/jjaf154
Citations
1
Primary Topic
Inflammatory Bowel Disease
Type
article
Field-Weighted Citation Impact
1.82
Controls
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article

Is 2nd JAKi treatment for UC worth the effort? A retrospective, multi-centre UK study

Rohith Kumar, Christopher A Lamb, Christian Selinger, Lucy Hicks et al.
1 citations
Journal of Crohn s and Colitis
Inflammatory Bowel Disease
1.82
article

Is 2nd JAKi treatment for UC worth the effort? A retrospective, multi-centre UK study

Rohith Kumar, Christopher A Lamb, Christian Selinger, Lucy Hicks, Chirag Patel, Chaonan Dong, Yaa Danso, Emma L. Davis, Anjan Dhar, Maria Bishara, Chandni Radia, Aileen Fraser, Paul Harrow, Mohammed Allah-Ditta, Mark Samaan, Lushen Pillay, Xin Yi Choon, Philip Harvey, Klaartje Bel Kok, Nicholas Burr, Alexander T. Elford, Konstantina Rosiou, Muhammad Azhar Hussain, Megan Rawcliffe, Tim Raine, Jie Han Yeo, Fiona Rees, Rachel Cooney, Puneet Chhabra, Alexandra Kent, Katie Yeung, Polychronis Pavlidis, Sara McCartney, Ally Speight, Charlie W. Lees, Jens Toft, Kamal Patel, Alissa J. Walsh, Jimmy K. Limdi, Dania Al-Zarrad, Hannah Trodden-Mittnacht, Karishma Sethi-Arora, Emma Johnston, Tariq Ahmad, Krishna Shah, Susan Ritchie, Roisin Campbell, Melissa F Hale, Becky George, Alice Hewitt, Nitish Jivan Sawan, Ruth Rudling, Sonia Kalyanji
article en
1 citations

Abstract

In this highly refractory cohort with active UC a second JAKi effectively achieved remission following IR to first JAKi. Type of first JAKi failure did not appear to influence clinical remission. No new safety signals were found.

Journal of Crohn s and ColitisVol. 19(9)
University of Wolverhampton (GB), University of Leeds (GB), University Hospitals Birmingham NHS Foundation Trust (GB), University College London Hospitals NHS Foundation Trust (GB), Imperial College Healthcare NHS Trust (GB), The University of Melbourne (AU), King's College London (GB), Guy's and St Thomas' NHS Foundation Trust (GB), Barts Health NHS Trust (GB), University of Exeter (GB), Leeds Teaching Hospitals NHS Trust (GB), Royal Devon & Exeter NHS Foundation Trust (GB), County Durham and Darlington NHS Foundation Trust (GB), Western General Hospital (GB), University Hospitals Bristol NHS Foundation Trust (GB), Salford Royal NHS Foundation Trust (GB), St George’s University Hospitals NHS Foundation Trust (GB), West Middlesex University Hospital (GB), Newcastle upon Tyne Hospitals NHS Foundation Trust (GB), Cambridge University Hospitals NHS Foundation Trust (GB), Edinburgh Cancer Research (GB), John Radcliffe Hospital (GB), Calderdale and Huddersfield NHS Foundation Trust (GB), Queen Elizabeth Hospital (GB), Sheffield Teaching Hospitals NHS Foundation Trust (GB), King's College Hospital NHS Foundation Trust (GB), St. Thomas Hospital (CA), Weston Area Health NHS Trust (GB), University Hospitals Sussex NHS Foundation Trust (GB), Torbay and South Devon NHS Foundation Trust (GB), The Royal Wolverhampton NHS Trust (GB), Wolverhampton Hospital (GB), Queen Elizabeth University Hospital (GB), Mid Yorkshire Hospitals NHS Trust (GB), St Mark's Hospital (GB), University College London (GB), Newcastle University (GB)
Good health and well-being
Openalex Percentile: Top 13%
Inflammatory Bowel Disease
1.82
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