The Changing Spectrum of Pediatric Allergic Contact Dermatitis: A Prospective Multicentric Study in Spain
<u><b><i></i></b></u> <u><b><i>Background:</i></b></u> Allergic contact dermatitis (ACD) is increasingly common in children, with age-related variations suggesting changing exposure patterns.<u><b><i>Objective:</i></b></u> Updating clinical and epidemiological characteristics, sensitization frequency, and relevance of positive patch tests in pediatric patients.<u><b><i>Methods:</i></b></u> This prospective multicenter study analyzed data from the Spanish Contact Dermatitis Research Group registry (REIDAC) for patients aged 0-16 years, stratified into 2 groups: 0-5 and 6-16 years. Participants were patch tested with the GEIDAC baseline and extended series from January 2019 to December 2023.<u><b><i>Results:</i></b></u> Patch tests were performed on 508 children, of whom 179 (35.2%) were sensitized. Among children aged 0-5 years (n = 41), 10 (24.4%) had positive patch tests, with lesions predominantly affecting the face (51.2%), hands (17.0%), and legs (4.9%). Atopic dermatitis (AD) was present in 36.6%, with linalool and limonene hydroperoxides as top sensitizers. In the 6-16 years group (n = 467), 169 patients (36.2%) were sensitized. AD was present in 45.0%, with lesions involving the face (24.0%), hands (23%), and legs (7.0%). Top allergens were linalool hydroperoxide and methylisothiazolinone.<u><b><i>Conclusions:</i></b></u> High sensitization proportions in both age groups highlight the importance of patch testing. Hydroperoxides of linalool and limonene are emerging as key sensitizers. Age-specific considerations may improve pediatric ACD management.
Authors
- Cristina Barrabés‐Torrella (ORCID: https://orcid.org/0000-0002-6600-7948)
- Paloma Sánchez‐Pedreño Guillén
- Pedro Mercader (ORCID: https://orcid.org/0000-0002-8309-9725)
- Javier Sánchez Pérez (ORCID: https://orcid.org/0000-0003-1240-1015)
- Miguel Lova Navarro (ORCID: https://orcid.org/0000-0002-1941-070X)
- Gemma Melé‐Ninot (ORCID: https://orcid.org/0000-0003-0365-0634)
- M. Rodríguez‐Serna (ORCID: https://orcid.org/0000-0002-2690-3668)
- Susana Córdoba Guijarro (ORCID: https://orcid.org/0000-0002-1809-4821)
- M.Á. Descalzo (ORCID: https://orcid.org/0000-0002-2262-7547)
- Mónica Munera‐Campos (ORCID: https://orcid.org/0000-0002-2227-2993)
- F.J. Ortiz de Frutos (ORCID: https://orcid.org/0000-0002-0635-0971)
- J.M. Carrascosa (ORCID: https://orcid.org/0000-0003-4266-0771)
- R. González‐Pérez (ORCID: https://orcid.org/0000-0001-5238-215X)
- Ana Maria Giménez‐Arnau (ORCID: https://orcid.org/0000-0001-5434-7753)
- David Pesqué (ORCID: https://orcid.org/0000-0002-5821-9780)
- J.F. Silvestre (ORCID: https://orcid.org/0000-0002-8532-6338)
- Ramón M. Pujol
- Tatiana Sanz‐Sánchez (ORCID: https://orcid.org/0000-0002-5796-7680)
- María A. Pastor‐Nieto (ORCID: https://orcid.org/0000-0001-8382-5419)
- Isidro Gonzáles (ORCID: https://orcid.org/0000-0003-3897-0195)
- Araceli Sánchez Gilo (ORCID: https://orcid.org/0000-0003-4941-6405)
- J Rodríguez (ORCID: https://orcid.org/0000-0001-6843-5877)
- María E. Gatica‐Ortega (ORCID: https://orcid.org/0000-0002-8203-5834)
- Rubén Linares‐Navarro (ORCID: https://orcid.org/0000-0002-6922-1173)
- Fátima Tous‐Romero (ORCID: https://orcid.org/0000-0002-3904-3396)
- Leopoldo Borrego (ORCID: https://orcid.org/0000-0002-0199-2756)
- Nidia Planella‐Fontanillas (ORCID: https://orcid.org/0009-0007-1303-2422)
- Violeta Zaragozá Ninet
- Enrique Gómez de la Fuente
- Javier Miquel Miquel
Institutions
- Universidad de Las Palmas de Gran Canaria (ES)
- Universitat Autònoma de Barcelona (ES)
- Universitat Pompeu Fabra (ES)
- Hospital Universitario Insular de Gran Canaria (ES)
- Hospital de Sant Pau (ES)
- Hospital Universitari i Politècnic La Fe (ES)
- Hospital General Universitario Morales Meseguer (ES)
- Hospital Universitario de Guadalajara (ES)
- Hospital Clínico Universitario de Valencia (ES)
- Hospital Universitario Rey Juan Carlos (ES)
- Hospital Universitario 12 De Octubre (ES)
- Spanish Academy of Dermatology and Venereology (ES)
- Hospital Universitario Araba (ES)
- Instituto de Investigación Biosanitaria de Granada (ES)
- Hospital Arnau de Vilanova (ES)
- Hospital General Universitario De Valencia (ES)
- Hospital Universitario de La Princesa (ES)
- Hospital Del Mar (ES)
- Hospital Universitari Sagrat Cor (ES)
- Hospital General Universitario de Alicante Doctor Balmis (ES)
- Hospital Universitario de Fuenlabrada (ES)
- Hospital Universitario Virgen de la Arrixaca (ES)
- Hospital Universitario Virgen del Rocío (ES)
- Hospital Universitari Germans Trias i Pujol (ES)
- Hospital Universitario de León (ES)
- Hospital Universitario Infanta Sofía (ES)
- Hospital Universitario Ramón y Cajal (ES)
- Complejo Hospitalario Universitario de Toledo (ES)
- Complejo Asistencial Universitario de Palencia (ES)
- Universidad de León (ES)
Publication Details
- Journal
- Dermatitis
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1177/17103568251368314
- Primary Topic
- Contact Dermatitis and Allergies
- Type
- article
- Field-Weighted Citation Impact
- 0.00