Translatable <i>in‐vivo</i> investigation of effects of progressive hypoxia in pregnancy on fetal cardiac structure and function in sheep
Progressive fetal hypoxia in sheep leads to profound changes in fetal cardiac structure and function, resulting from a switch to LV dominance triggered by fetal brain sparing. The findings also indicate that fetal cardiac compensatory reserves become exhausted with progressive hypoxia. © 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
Authors
- Youguo Niu (ORCID: https://orcid.org/0000-0002-8843-9952)
- B. Thilaganathan (ORCID: https://orcid.org/0000-0002-5531-4301)
- Conrado Milani Coutinho (ORCID: https://orcid.org/0000-0003-1966-0466)
- Kimberley J. Botting (ORCID: https://orcid.org/0000-0003-4290-9821)
- Olga Patey (ORCID: https://orcid.org/0000-0001-8008-5144)
- Dino A. Giussani (ORCID: https://orcid.org/0000-0002-1308-1204)
- Sage G. Ford (ORCID: https://orcid.org/0000-0001-5542-0545)
- Lin Zhang (ORCID: https://orcid.org/0000-0003-2994-2053)
- Jin Ma (ORCID: https://orcid.org/0000-0001-6802-455X)
- Wen Tong (ORCID: https://orcid.org/0000-0003-1647-4166)
Institutions
- Universidade de São Paulo (BR)
- University of Cambridge (GB)
- Royal Brompton & Harefield NHS Foundation Trust (GB)
- St George’s University Hospitals NHS Foundation Trust (GB)
- Royal Brompton Hospital (GB)
- Air Force Medical University (CN)
Publication Details
- Journal
- Ultrasound in Obstetrics and Gynecology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1002/uog.29306
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- British Heart Foundation
- University of Cambridge
- Fundação de Amparo à Pesquisa do Estado de São Paulo