Design and Evaluation of Next-Generation HIV Genotyping for Detection of Resistance Mutations to 28 Antiretroviral Drugs Across 5 Major Classes Including Lenacapavir
PHG demonstrates significant improvements over standard-care HIV genotyping, offering deeper insights into LEN resistance, minority variants, and cross-class resistance using a low-cost, high-throughput portable sequencing technology and publicly available cloud computing.
Authors
- J. Kim
- Pamina M. Gorbach (ORCID: https://orcid.org/0000-0003-2100-7765)
- Christian Takayama
- Martin V. Sattah
- Robert W. Shafer (ORCID: https://orcid.org/0000-0003-2513-2643)
- Jenica Ryu
- Sung Yong Park (ORCID: https://orcid.org/0000-0002-5180-3853)
- Ha Youn Lee (ORCID: https://orcid.org/0000-0001-7260-2383)
- Zachariah Badii
Institutions
- University of Southern California (US)
- University of California, Los Angeles (US)
- Los Angeles Medical Center (US)
- Stanford Medicine (US)
- Stanford University (US)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1093/cid/ciaf458
- Citations
- 1
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.40