Antimicrobial Usage Among Acutely Ill Hospitalized Children Aged 2‒23 Months in Sub-Saharan Africa and South Asia
Antimicrobial use was similar across sites, with some overuse and notably limited escalation and de-escalation, likely due to guideline adherence. Guidelines need updating for the absence of relevant antimicrobial sensitivities, to include risk-based antimicrobial prescribing considering mortality risk and prior exposure to antimicrobials and the hospital environment. Hence, clinical trials of risk-differentiated care are needed.
Authors
- Céline Bourdon (ORCID: https://orcid.org/0000-0002-6336-0906)
- Moses Mburu (ORCID: https://orcid.org/0000-0001-7281-583X)
- Robert Musyimi (ORCID: https://orcid.org/0000-0001-9810-8367)
- Abu Sadat Mohammad Sayeem Bin Shahid (ORCID: https://orcid.org/0000-0002-7759-974X)
- Robert Bandsma (ORCID: https://orcid.org/0000-0001-6358-4750)
- Nicole Stoesser (ORCID: https://orcid.org/0000-0002-4508-7969)
- Christina Lancioni (ORCID: https://orcid.org/0000-0002-0821-1211)
- Molly Timbwa
- James Alexander Berkley (ORCID: https://orcid.org/0000-0002-1236-849X)
- Caroline Tigoi (ORCID: https://orcid.org/0000-0003-2750-7533)
- Judd L. Walson (ORCID: https://orcid.org/0000-0003-4836-720X)
- Christopher Maronga (ORCID: https://orcid.org/0000-0003-2374-7046)
- Wieger P. Voskuijl (ORCID: https://orcid.org/0000-0001-5825-2831)
- Ezekiel Mupere (ORCID: https://orcid.org/0000-0002-8746-9009)
- Zaubina Kazi (ORCID: https://orcid.org/0000-0003-3669-0851)
- Agnes Ndirangu (ORCID: https://orcid.org/0000-0002-5911-8121)
- Moses M. Ngari (ORCID: https://orcid.org/0000-0001-7149-5491)
- Narshion Ngao (ORCID: https://orcid.org/0000-0002-0144-9577)
- Kirkby D. Tickell (ORCID: https://orcid.org/0000-0002-4108-1236)
- Shalton Mwaringa (ORCID: https://orcid.org/0009-0003-5944-6402)
- Ali Faisal Saleem (ORCID: https://orcid.org/0000-0003-1804-9868)
- Tahmeed Ahmed (ORCID: https://orcid.org/0000-0002-4607-7439)
- Benson O. Singa (ORCID: https://orcid.org/0000-0002-6605-324X)
- Mohammod Jobayer Chisti (ORCID: https://orcid.org/0000-0001-9958-3071)
- Priya Sukhtanar
- Abdoulaye Diallo
- Muzammil Shabana Ejaz
- Al Fazal Khan
- Fehmina Arif
Institutions
- Aga Khan University (PK)
- Université Joseph Ki-Zerbo (BF)
- Johns Hopkins University (US)
- University of Malawi (MW)
- Oregon Health & Science University (US)
- University of Washington (US)
- International Centre for Diarrhoeal Disease Research (BD)
- Kamuzu Central Hospital (MW)
- Hospital for Sick Children (CA)
- Kenya Medical Research Institute (KE)
- University of Oxford (GB)
- Emma Kinderziekenhuis (NL)
- Blantyre Institute for Community Ophthalmology (MW)
- Centre for Global Health Research (CA)
- SickKids Foundation (CA)
- Oxford BioMedica (United Kingdom) (GB)
- Makerere University (UG)
- Wellcome Trust (GB)
- University of Amsterdam (NL)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-08-10
- DOI
- https://doi.org/10.1093/ofid/ofaf487
- Primary Topic
- Antibiotic Use and Resistance
- Type
- article
- Field-Weighted Citation Impact
- 0.00