Coronary Artery Bypass Grafting Versus Percutaneous Coronary Intervention for Left Main Coronary Artery Disease—Long-Term Outcomes

<b>Background</b>: The optimal revascularization strategy for patients with left main coronary artery (LMCA) disease has been repeatedly addressed in randomized controlled trials (RCTs), although outcomes from real-life clinical studies are still poorly investigated. <b>Objectives</b>: This retrospective study aimed to assess the complete 5-year outcomes for individuals with multivessel coronary artery disease (MVD) involving LMCA disease treated with coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) as recommended by a local HT. <b>Methods</b>: From 2016 to 2019, 176 Heart Team (HT) meetings were held. Primary and secondary endpoints of 267 patients with MVD involving LMCA disease qualified either for CABG or PCI (109 and 158 patients, respectively) with subsequent optimal medical therapy (OMT) were assessed. The primary endpoint of the study was as an overall mortality, while secondary endpoints contained major adverse cardiac and cerebrovascular events (MACCE)-specifically, stroke, myocardial infarction (MI), repeat revascularization (RR), and the individual components of MACCE. <b>Results</b>: At 5 years, we found no significant difference in overall mortality between the both cohorts (22.9%-CABG vs. 24.7%-PCI, <i>p</i> = 0.74). The rate of MI was higher in patients treated percutaneously (7.3% vs. 15.8% for PCI, <i>p</i> = 0.04), while the incidence of stroke was higher in patients who underwent CABG (3.8% vs. 11.0% for CABG, <i>p</i> = 0.02). A MACCE occurrence was higher in PCI cohort (77.2% vs. 55.0%, <i>p</i> < 0.001), mainly driven by higher rates of RR was higher in patients treated percutaneously (32.9% vs. 13.8%, <i>p</i> < 0.001). <b>Conclusions:</b> For patients with LMCA disease, neither CABG nor PCI following HT decisions showed overwhelming superiority in real-life clinical practice: occurrence of all-cause death was similar, rates of MACCE, MI, and repeat revascularization advocated CABG, while incidence of strokes favored PCI.