Lipid profiling reveals unsaturated lipid reduction in women with Alzheimer's disease
Lipid profiling showed lipid changes associated with Alzheimer's disease (AD) exclusively in women. Women with AD had fewer highly unsaturated lipids and more saturated lipids. Unsaturated phospholipids affected AD independently of cholesterol, low-density lipoprotein, or apolipoprotein B. Sex-stratified analysis is key to understanding the different manifestations of AD.
Authors
- Asger Wretlind (ORCID: https://orcid.org/0000-0001-6083-5227)
- Petroula Proitsi (ORCID: https://orcid.org/0000-0002-2553-6974)
- Cristina Legido‐Quigley (ORCID: https://orcid.org/0000-0002-4018-214X)
- Latha Velayudhan (ORCID: https://orcid.org/0000-0002-7712-930X)
- Wenqiang Chen (ORCID: https://orcid.org/0009-0006-6864-9932)
- Jin Xu (ORCID: https://orcid.org/0009-0002-8157-1608)
- Nicholas J. Ashton
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0002-4671-6763)
Institutions
- Steno Diabetes Centers (DK)
- Harvard University (US)
- Queen Mary University of London (GB)
- King's College London (GB)
- Sahlgrenska University Hospital (SE)
- Institute for Neurodegenerative Disorders (US)
- UK Dementia Research Institute (GB)
- MRC Prion Unit (GB)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/alz.70512
- Citations
- 6
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- Alzheimer's Research Trust
- H. Lundbeck A/S