Adipose Tissue Estrogen Receptor-Alpha Overexpression Ameliorates High-Fat Diet–Induced Adipose Tissue Inflammation
Adipo-ERα↑ elicits distinct sex-specific effects with respect to body composition and hepatic lipid accumulation, which are likely driven by variations in circulating and tissue estrogen levels. Nonetheless, despite differences in estrogen levels, Adipo-ERα↑ profoundly reduced obesity-linked adipose tissue inflammation in both sexes, providing further evidence that therapeutically targeting ERα may be beneficial for treating obesity-associated inflammation.
Authors
- William E. Cotham
- Ahmed Al-Adhami (ORCID: https://orcid.org/0000-0002-9072-551X)
- Christian Unger (ORCID: https://orcid.org/0000-0002-4216-3575)
- Marion C Hope (ORCID: https://orcid.org/0000-0002-4855-5764)
- Reilly T. Enos (ORCID: https://orcid.org/0000-0001-5571-4586)
- Cassidy E Socia
- Diego Altomare (ORCID: https://orcid.org/0000-0002-9126-5703)
- M Chase Kettering
- Darya S Niamira
- Barton C Rice
- Ben P Wiznitzer
Institutions
- University of South Carolina (US)
Publication Details
- Journal
- Journal of the Endocrine Society
- Published
- 2025-08-16
- DOI
- https://doi.org/10.1210/jendso/bvaf134
- Citations
- 3
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- National Science Foundation
- Georgetown University
- University of South Carolina
- National Institutes of Health
- National Institute of General Medical Sciences