<i>ABCA7</i> deletion lowers age at onset of Alzheimer's disease and interacts with <i>APOE</i> ε4 synergistically in African‐ancestry populations
AA-specific ABCA7 deletion lowers AAO of AD in APOE ε3/ε4 carriers from AA populations. Findings suggest an interaction between ABCA7 deletion and APOE ε4 on AAO. APOE ε4 has a strong, dose-dependent effect on AAO of AD in AA individuals. ABCA7 deletion impact on AAO of AD is stronger in females with APOE ε3/ε4.
Authors
- Andrew Zaman (ORCID: https://orcid.org/0000-0002-6479-6883)
- Patrice Whitehead
- Kamada Lwere (ORCID: https://orcid.org/0000-0002-4235-7054)
- Bilçağ Akgün (ORCID: https://orcid.org/0000-0002-5220-5652)
- Gary W. Beecham (ORCID: https://orcid.org/0000-0002-7061-6332)
- Joshua Odunayo Akinyemi (ORCID: https://orcid.org/0000-0002-0675-2110)
- Oladotun Olalusi (ORCID: https://orcid.org/0000-0002-2842-3545)
- Rufus Akinyemi (ORCID: https://orcid.org/0000-0001-5286-428X)
- Samuel Diala
- Adesola Ogunniyi (ORCID: https://orcid.org/0000-0002-2946-8956)
- Susan H. Blanton (ORCID: https://orcid.org/0000-0002-5433-3439)
- Goldie S. Byrd (ORCID: https://orcid.org/0000-0003-1057-0261)
- Biniyam A. Ayele (ORCID: https://orcid.org/0000-0002-7955-6030)
- Mayowa Ogunronbi (ORCID: https://orcid.org/0000-0003-4104-2728)
- Michael L. Cuccaro (ORCID: https://orcid.org/0000-0003-4769-0785)
- Jeffery M. Vance (ORCID: https://orcid.org/0000-0003-3815-8199)
- Kazeem Akinwande (ORCID: https://orcid.org/0000-0002-1472-3344)
- Motunrayo Mojoyin Coker (ORCID: https://orcid.org/0000-0003-4445-914X)
- Raj N. Kalaria (ORCID: https://orcid.org/0000-0001-7907-4923)
- Takiyah D. Starks (ORCID: https://orcid.org/0000-0001-7267-3480)
- Reginald Obiako (ORCID: https://orcid.org/0000-0003-1769-8110)
- William S. Bush (ORCID: https://orcid.org/0000-0002-9729-6519)
- Reneé A. Laux
- Albert Akpalu (ORCID: https://orcid.org/0000-0002-4802-9852)
- Paula Ogrocki
- Pedro Mena (ORCID: https://orcid.org/0000-0003-2150-2977)
- Fred Stephen Sarfo (ORCID: https://orcid.org/0000-0001-7274-5093)
- Njideka Okubadejo (ORCID: https://orcid.org/0000-0003-2975-8803)
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Alexander Gulyayev (ORCID: https://orcid.org/0000-0001-5098-4675)
- Albertino Antonio Moura Damasceno (ORCID: https://orcid.org/0000-0003-0925-494X)
- Margaret A. Pericak‐Vance
- David M. Ndetei (ORCID: https://orcid.org/0000-0002-2433-6225)
- Allison Caban‐Holt (ORCID: https://orcid.org/0000-0001-5393-9116)
- Christiane Reitz
- Farid Rajabli
- Kara L. Hamilton‐Nelson
- Izri Martinez
- Larry D. Adams
- Brian W. Kunkle
- Jenny Chavez
- Katalina McInerney
- Jonathan L. Haines
Institutions
- Ahmadu Bello University (NG)
- University of Miami (US)
- Eduardo Mondlane University (MZ)
- University of Ibadan (NG)
- University of Lagos (NG)
- University Hospitals of Cleveland (US)
- University College Hospital, Ibadan (NG)
- Korle Bu Teaching Hospital (GH)
- Kwame Nkrumah University of Science and Technology (GH)
- Dr. John T. Macdonald Foundation (US)
- Africa Mental Health Foundation (KE)
- Addis Ababa University (ET)
- Wake Forest University (US)
- Case Western Reserve University (US)
- Makerere University (UG)
- Columbia University (US)
- Newcastle University (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/alz.70583
- Citations
- 2
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- National Institutes of Health
- National Institute on Aging