Design, Synthesis and Anti-Inflammation Evaluation of N-Acyl Tryptophan Derivatives as Promising P2Y14R Antagonists Against Lipopolysaccharide-Induced Acute Lung Injury
Compound <b>II-3</b> with potent P2Y<sub>14</sub>R antagonistic activity, may be a promising candidate for further investigation as an anti-inflammatory drug.
Authors
- Yongfang Yao (ORCID: https://orcid.org/0000-0001-6455-1213)
- Chuanjun Song (ORCID: https://orcid.org/0000-0001-7733-578X)
- Yongtao Duan
- Moran Sun (ORCID: https://orcid.org/0000-0001-6577-0733)
- Wenjing Liu (ORCID: https://orcid.org/0000-0001-5081-9047)
- Yuyang Wang
- Mingzhu Wang (ORCID: https://orcid.org/0000-0003-1416-2759)
- Yuanzhe Li (ORCID: https://orcid.org/0000-0001-7530-8286)
- Shiyu Ma (ORCID: https://orcid.org/0000-0003-1484-8750)
- Bingqian Han
Institutions
- Zhengzhou University (CN)
- Henan University of Engineering (CN)
- Zhengzhou Children's Hospital (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-08-01
- DOI
- https://doi.org/10.2147/dddt.s497291
- Citations
- 1
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.12