Electroacupuncture Improves Microglial Polarization Induced‐Inflammation by Regulating the <scp>TGF</scp>‐β/Smad‐3 Signaling Pathway in Ischemic Stroke Mice
EA may inhibit the M1 polarization of microglia/macrophages and provide a protective effect against ischemic brain injury by modulating the TGF-β/Smad-3 signaling pathway. These findings suggest that EA could be a potential therapeutic strategy for IS treatment.
Authors
- Dechou Zhang
- Xuehui Fan (ORCID: https://orcid.org/0000-0001-9040-1155)
- Maryam Mazhar (ORCID: https://orcid.org/0000-0002-1944-159X)
- Guoqiang Yang (ORCID: https://orcid.org/0000-0001-6202-7485)
- Guiquan Chen (ORCID: https://orcid.org/0000-0002-4674-5548)
- Yong Liu (ORCID: https://orcid.org/0000-0003-1278-7114)
- Yue Yuan (ORCID: https://orcid.org/0009-0003-3723-8178)
- Liulu Zhang
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1111/cns.70567
- Citations
- 3
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.53
Funders
- National Natural Science Foundation of China
- Southwest Medical University
- Health Commission of Sichuan Province
- Sichuan Province Science and Technology Support Program