HER2 alterations across solid tumors: implications for comprehensive testing
This study highlights ERBB2 alterations across diverse cancers, demonstrating their heterogeneity and clinical significance. ERBB2 mutation-carrying tumors are less likely to have HER2 protein 3+ expression or CN amplification, indicating the need for comprehensive genomic analysis to identify those patients. In the context of pan-tumor approval of T-DXd for HER2, findings support integrating genomic and phenotypic data to enhance diagnostic precision and inform therapeutic decision-making. Comprehensive ERBB2 (HER2) testing across tumor types is essential to expand access to HER2-targeted therapies.
Authors
- Arnab Basu (ORCID: https://orcid.org/0000-0002-8678-3880)
- M. Midhun (ORCID: https://orcid.org/0000-0002-0673-1811)
- Chinmay Jani (ORCID: https://orcid.org/0000-0002-6917-5568)
- Tyler Mattox (ORCID: https://orcid.org/0000-0002-8323-0535)
- Garima Gupta (ORCID: https://orcid.org/0000-0002-8730-006X)
- Rebecca C. Arend (ORCID: https://orcid.org/0000-0003-2108-3426)
- Cyntanna C. Hawkins (ORCID: https://orcid.org/0000-0001-6488-0244)
- Yanis Boumber (ORCID: https://orcid.org/0000-0001-5003-248X)
- Bassel F. El‐Rayes (ORCID: https://orcid.org/0000-0002-2661-5746)
- Aakash Desai (ORCID: https://orcid.org/0000-0002-2943-3817)
- Mehmet Akce (ORCID: https://orcid.org/0000-0003-4747-7722)
- Sejong Bae (ORCID: https://orcid.org/0000-0001-9982-3223)
- Ahmed Ismail (ORCID: https://orcid.org/0000-0003-4562-5779)
- Nusrat Jahan (ORCID: https://orcid.org/0009-0001-4704-3249)
Institutions
- Eastern Virginia Medical School (US)
- University of Alabama at Birmingham (US)
- Caris Life Sciences (United States) (US)
- Sylvester Comprehensive Cancer Center (US)
- Old Dominion University (US)
Publication Details
- Journal
- The Oncologist
- Published
- 2025-08-16
- DOI
- https://doi.org/10.1093/oncolo/oyaf258
- Citations
- 1
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Daiichi Sankyo Europe