Expression patterns of TROP2 and Nectin-4 in oropharyngeal squamous cell carcinoma in relation to HPV status: potential biomarkers for targeted therapy
This study is one of the first to investigate the expression of Nectin-4 and TROP2 in a cohort of both HPV-positive and HPV-negative OSCC patients. Our results indicate that TROP2 is almost universally expressed in OSCC, while Nectin-4 expression is less frequent. TROP2 and Nectin-4 are promising therapeutic targets for OSCC, with Nectin-4 being particularly relevant for HPV-positive patients. Clinical trials are necessary to confirm the clinical relevance and efficacy of ADCs targeting TROP2 and Nectin-4 in OSCC treatment.
Authors
- Nora Wuerdemann
- Shachi Jenny Sharma (ORCID: https://orcid.org/0000-0002-2768-7936)
- Alexander Quaas (ORCID: https://orcid.org/0000-0002-9644-2115)
- Marcel Mayer (ORCID: https://orcid.org/0000-0001-9963-1109)
- Louis Jansen (ORCID: https://orcid.org/0000-0003-0332-1099)
- Su Ir Lyu (ORCID: https://orcid.org/0009-0002-4125-6048)
- Hans Nikolaus Caspar Eckel (ORCID: https://orcid.org/0000-0002-6947-9836)
- Julia Eßer (ORCID: https://orcid.org/0009-0002-3556-3738)
- Charlotte Klasen (ORCID: https://orcid.org/0009-0009-3120-0439)
- Jens Peter Klußmann (ORCID: https://orcid.org/0000-0002-8223-7954)
- Helen Abing (ORCID: https://orcid.org/0000-0001-8453-842X)
- Malte Suchan
- Kariem Sharaf (ORCID: https://orcid.org/0000-0001-7799-4005)
- Karl Knipper (ORCID: https://orcid.org/0009-0008-7133-3538)
- Kevin Hansen (ORCID: https://orcid.org/0000-0001-5028-0600)
- Arthur Charpentier (ORCID: https://orcid.org/0000-0001-9636-7437)
- Joseph Böckelmann
Institutions
- University of Cologne (DE)
- Düsseldorf University Hospital (DE)
- University Hospital Cologne (DE)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Therapeutic Advances in Medical Oncology
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1177/17588359251361877
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00