Advanced oxidation protein products accelerates paracetamol-induced liver injury through AMPK-mTOR signaling pathway in chronic kidney disease
These findings suggest that the AMPK-mTOR signaling pathway mediates the worsening of paracetamol-induced liver injury in CKD, with AOPPs potentially serving as key endogenous factors. This study lays the groundwork for identifying crucial molecules involved in exacerbated paracetamol-induced liver injury in CKD, which may serve as new drug targets and improve the safety profile of paracetamol in patients with CKD.
Authors
- Tianrong Xun (ORCID: https://orcid.org/0000-0002-3786-0659)
- Zixi Hong
- Jingqian Zhao
- Zhufen Lin
- Haixing Feng (ORCID: https://orcid.org/0000-0002-6580-3280)
- Xiaokang Wang (ORCID: https://orcid.org/0000-0002-4325-9907)
- Huanhuan Liu (ORCID: https://orcid.org/0000-0002-7196-4013)
- Wei Sui (ORCID: https://orcid.org/0009-0005-5182-5621)
- Mimi Zhang (ORCID: https://orcid.org/0000-0003-3273-540X)
- Xixiao Yang (ORCID: https://orcid.org/0000-0001-9991-3229)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Longgang Central Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Journal of Pharmacy and Pharmacology
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1093/jpp/rgaf069
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00