Reduced Platelet Aggregation and Plasma Cytokine Levels Mitigate Progressive Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Reduced platelet aggregation is associated with attenuation of MASLD features. Antiplatelet therapy correlates with decreased pro-inflammatory and pro-fibrotic chemokine signaling linked to the morphological characteristics of MASLD. Assessment of platelet reactivity and specific chemokines may enhance understanding of MASLD pathophysiology and support the development of novel therapeutic strategies.
Authors
- Jessica Kristin Henes (ORCID: https://orcid.org/0000-0001-8146-1199)
- Anne‐Katrin Rohlfing (ORCID: https://orcid.org/0000-0001-5469-3648)
- Michal Droppa (ORCID: https://orcid.org/0000-0001-5807-7615)
- Malte N. Bongers (ORCID: https://orcid.org/0000-0003-2852-0270)
- Dominik Rath (ORCID: https://orcid.org/0000-0002-5008-2572)
- Tobias Harm (ORCID: https://orcid.org/0000-0002-6121-2694)
- Meinrad Gawaz (ORCID: https://orcid.org/0000-0003-1124-9592)
- K. Müller (ORCID: https://orcid.org/0000-0002-4469-7052)
- Mathias Heikenwaelder
- Nicole Manzat
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Children's Hospital Tübingen (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-08-01
- DOI
- https://doi.org/10.2147/jir.s533707
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Deutsche Gesellschaft für Kardiologie-Herz und Kreislaufforschung.