Effect of Noopept Dipeptide Administration on Improving Spatial Memory and Pain during Persistent Peripheral Inflammation in Male Rats

Introduction:Cognition impairments are commonly associated with pain experiences.Noopept drug leads to impaired spatial memory improvement by affecting the process of neuronal damage and repair in reducing and modulating pain.Therefore, in this study, changes in spatial learning and memory performance during chronic peripheral inflammatory pain and also, the effect of Noopept on these changes were investigated. Materials and Methods:Rats were divided two into main groups (CFA and CFA+Noopept), namely CFA group which received 100 L CFA and CFA+Noopept group which received 100 L CFA+5mg/kg/day Noopept.After that, each group was divided into three subgroups (0, 7 and 21days) based on different time points of the study.Thermal hyperalgesia and learning and spatial memory assessed at 0, 7, 21 days of study after Persistent inflammation induction by CFA.Results: Our finding indicated that thermal hyperalgesia significantly increased on day 7 following CFA injection in comparison to day 0 (p<0.001) that is, administration of Noopept decreased thermal hyperalgesia on day 7(p<0.01).However, a significant decrease was observed in thermal hyperalgesia on day 21 in comparison to day 7 in CFA group (p<0.01).In addition, we indicated that CFA-induced pain impaired spatial learning and memory functions on day 7 (p<0.01).Daily administration of Noopept improved spatial memory and learning impairments on day 7(p<0.05). Conclusion:It seems that acute and chronic peripheral inflammatory pain impairs spatial learning and memory.Daily administration of Noopept can improve behavioral impairments of pain, spatial learning and memory.