The Effect of a Period of Resistance Exercise with Two Different Intensities and Recovery on Tumor Necrosis Factor-Alpha, 70 Kilodalton Heat Shock Protein, C-Reactive Protein, and Brain-Derived Neurotrophic Factor in Blood Plasma in Female Bodybuilde

Introduction:Resistance training with high loads of HLRT causes physiological changes in the immune system, affecting the athlete's health and performance.This study investigated the effect of a period of resistance activity with two different intensities and recovery on TNF -, hs-CRP, HSP-70, and BDNF in the blood serum of female bodybuilders. Materials and Methods:In this semi-experimental study, 12 healthy female bodybuilders (age 305) volunteers, after filling out the consent form, performed exercise programs with 70% and 85% 1RM intensities and two recovery times of one and two minutes.36 hours after each exercise, blood sampling was done after fasting for 10 hours.Plasma was separated from blood cells by centrifuging at 4000g for 10 min, clear plasma supernatant was aliquot, and stored at -20C until required for use.In the end, all levels of TNF-, hs-CRP, HSP-70, and BDNF were checked simultaneously.SPSS version 27 software was used to analyze the data at a significance level of p0.05. Results:Based on the results, high-intensity resistance training (HLRT) compared to moderate-intensity resistance training (MLRT), with an increase in training intensity up to 85% 1RM and a one-minute recovery, significantly reduced TNF- levels (p<0.001), and hs-CRP (p<0.025) and HSP-70 (p<0.0001), also resulted in a significant increase in BDNF serum level (p<0.0001). Conclusion:Increasing the intensity of HLRT resistance training has no negative effect on the immune system, and this is probably due to the reduction of the pro-inflammatory factors TNF-, hs-CRP, and HSP-70 and the increase of the BDNF factor in female bodybuilders.