Nuciferine inhibits pressure overload-induced cardiac remodeling by activating the SENP1-ACSL4-ferroptosis axis
This study is the first to clarify that NF inhibits cardiomyocyte ferroptosis via the SENP1-ACSL4 axis to generate cardiovascular beneficial effects. More significantly, our work demonstrated that NF is an effective medicine with clinical translational promise, and that targeting ACSL4 and SENP1 can provide novel therapies for patients with cardiac remodeling and heart failure.
Authors
- Hong-liang Qiu
- Yan Che (ORCID: https://orcid.org/0000-0002-4944-3860)
- Qizhu Tang (ORCID: https://orcid.org/0000-0003-2210-3169)
- Yuan Yuan
- Yuting Liu (ORCID: https://orcid.org/0000-0001-9175-514X)
- Yu‐An Ding (ORCID: https://orcid.org/0000-0002-9408-2419)
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1016/j.jare.2025.08.020
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- National Key Research and Development Program of China