Exercise improves hypobaric hypoxia-induced skeletal muscle dysfunction via Sirt1-Mediated myotube and mitochondrial remodeling
This study uncovers exercise as a potent inducer of hypoxia resilience through Sirt1-dependent mitochondrial repair and multicellular crosstalk (vascular-endothelial-satellite cell axis). Our "train-before-you-climb" approach could transform how we prepare for high-altitude living, offering a drug-free way to keep muscles strong where the air is thin.
Authors
- Wugui Chen
- Honghong Chen (ORCID: https://orcid.org/0000-0001-9682-5709)
- Jun Chang (ORCID: https://orcid.org/0000-0001-9616-279X)
- Mengting He (ORCID: https://orcid.org/0009-0007-2987-9070)
- Chun‐Yen Lin (ORCID: https://orcid.org/0000-0003-3007-3190)
- Jintao He (ORCID: https://orcid.org/0009-0008-6284-4299)
- Xinhua Liu (ORCID: https://orcid.org/0000-0002-9972-8215)
- Yuyu Zhang (ORCID: https://orcid.org/0000-0003-3095-3083)
- Yajie Hu (ORCID: https://orcid.org/0000-0001-5976-3094)
- Jialin Zhao (ORCID: https://orcid.org/0000-0002-3929-3862)
- Caiyun Wang (ORCID: https://orcid.org/0000-0003-0932-3650)
Institutions
- Fujian Medical University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Pudong Medical Center (CN)
- Second Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1016/j.jare.2025.08.022
- Citations
- 2
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- National Science and Technology Major Project
- National Key Research and Development Program of China