Multiple organs exhibit exacerbated cachexia in male mice with colon cancer than females
Overall, we herein report a novel direct role of 17β-estradiol on colon cancer cells explaining why multiple tissues from males display more signs of cachexia than females.
Authors
- Andrea David Re Cecconi (ORCID: https://orcid.org/0000-0003-1502-9108)
- Mara Barone (ORCID: https://orcid.org/0000-0002-2947-9209)
- Fulvia Cerruti
- Laura Pasetto (ORCID: https://orcid.org/0000-0003-0319-4448)
- Martina Lunardi (ORCID: https://orcid.org/0000-0003-2011-5131)
- Federica Palo (ORCID: https://orcid.org/0000-0002-7472-8753)
- Davide Olivari (ORCID: https://orcid.org/0000-0003-0802-6603)
- Lorenzo Castagnoli (ORCID: https://orcid.org/0000-0002-0220-6497)
- Angelo Poletti (ORCID: https://orcid.org/0000-0002-8883-0468)
- Valentina Bonetto (ORCID: https://orcid.org/0000-0003-0456-2054)
- Paolo Cascio (ORCID: https://orcid.org/0000-0001-7801-251X)
- M. Galbiati (ORCID: https://orcid.org/0000-0003-3250-5591)
- Rosanna Piccirillo (ORCID: https://orcid.org/0000-0002-1613-9352)
- Martina Bigliardi
Institutions
- University of Milan (IT)
- Mario Negri Institute for Pharmacological Research (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- University of Turin (IT)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1016/j.jare.2025.08.028
- Citations
- 3
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Ministero della Salute
- Associazione Italiana per la Ricerca sul Cancro