In Vivo Bio-Impedance Sensing Capsule Study for Monitoring Mucosal Permeability in a DSS-Colitis Rat Model
This manuscript presents the implementation of a Bluetooth-enabled ingestible sensing capsule for real-time, in vivo monitoring of mucosal permeability. The device utilizes a flexible polymer-coated MEMS impedance sensor for highly targeted monitoring of epithelial tissues. In the first demonstration of its kind, the device is surgically implanted into rat cecum and leverages electrochemical impedance spectroscopy (EIS) to profile mucosal integrity in an inflammatory rodent model using a dextran sodium sulfite (DSS) challenge. On average, the capsule wirelessly reported a 32.5% reduction in cecal bioimpedance corresponding to DSS-induced mucosal disruption and establishing the first clinical benchmark for impedance-based characterization of intestinal tissue integrity.
Authors
- Younggeon Jin (ORCID: https://orcid.org/0000-0003-2450-9330)
- Justin M. Stine (ORCID: https://orcid.org/0000-0002-2693-6400)
- Luke A. Beardslee (ORCID: https://orcid.org/0000-0002-5713-5059)
- Jingxi Chen (ORCID: https://orcid.org/0000-0002-1953-8041)
- Bill Holt
- Reza Ghodssi (ORCID: https://orcid.org/0000-0002-3716-4901)
- Malcolm Lim (ORCID: https://orcid.org/0000-0003-3691-4368)
- Jain Kim
- Hammed Ayansola
Institutions
- University System of Maryland (US)
- Earth System Science Interdisciplinary Center (US)
- University of Maryland, College Park (US)
Publication Details
- Published
- 2025-06-29
- DOI
- https://doi.org/10.1109/transducers61432.2025.11109391
- Citations
- 1
- Primary Topic
- Microscopic Colitis
- Type
- article
- Field-Weighted Citation Impact
- 1.35