Advanced Digital Microfluidic Platform with Integrated SERS Sensor for On-Site Processing and Detection
This study presents an integrated digital microfluidic (DMF) platform combined with a surface-enhanced Raman spectroscopy (SERS) sensor for automated on-chip sample processing and detection. The system utilizes embossing technology to fabricate a semi-transparent SERS amplification stack (STSAS) integrated directly onto the DMF chip, enabling efficient exosome isolation and label-free SERS detection. Experimental results show a further 33% enhancement in SERS signal intensity, demonstrating the system's high sensitivity, stability, and reproducibility. The platform offers a versatile solution for real-time diagnostics, biomarker detection, and disease monitoring, with applications in clinical and environmental analysis.
Authors
- Shuailong Zhang (ORCID: https://orcid.org/0000-0003-1004-021X)
- Rongxin Fu (ORCID: https://orcid.org/0000-0002-4547-2269)
- Wenbo Dong (ORCID: https://orcid.org/0009-0002-4142-6123)
- Qian Yu (ORCID: https://orcid.org/0000-0002-1436-6025)
Institutions
- Beijing Institute of Technology (CN)
Publication Details
- Published
- 2025-06-29
- DOI
- https://doi.org/10.1109/transducers61432.2025.11111305
- Primary Topic
- Electrowetting and Microfluidic Technologies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality
- Natural Science Foundation of Chongqing
- National Key Research and Development Program of China