A Silk-Based Bidirectional Flexible Extravascular Biointerface

In this article, we present a silk-based bidirectional and flexible extravascular bio-interface designed for the monitoring and regulation of vascular electrical activity, which is closely associated with sympathetic nervous system. By incorporating bioadhesive and biocompatible silk fibroin materials, the biointerface exhibits waterproof adhesive properties and conforms seamlessly to the curved, three-dimensional surface of blood vessels without the need for additional fixation tools. The supreme electrical properties of the extravascular biointerface facilitate reliable, high-resolution electrophysiological signal acquisition and effective neural stimulation, which is validated via in vivo experiments. This novel bidirectional, flexible extravascular biointerface holds potential for advancing clinical electronic medicine for cardiovascular disease management.